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Published February 1, 2002 | public
Journal Article

Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila


Individual members of gene families often have partially redundant functions during nervous system development, making conventional genetic analysis problematic. Here we review experiments showing that several genes can be silenced together by injection of double-stranded RNAs into wild-type Drosophila embryos. By dye-labeling single neuroblasts in injected embryos, the effects of multigene silencing on individual CNS axon pathways can now be examined.

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© 2002 Elsevier Science Ltd.

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