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Published January 2015 | Accepted Version
Journal Article Open

R3 receptor tyrosine phosphatases: Conserved regulators of receptor tyrosine kinase signaling and tubular organ development


R3 receptor tyrosine phosphatases (RPTPs) are characterized by extracellular domains composed solely of long chains of fibronectin type III repeats, and by the presence of a single phosphatase domain. There are five proteins in mammals with this structure, two in Drosophila and one in Caenorhabditis elegans. R3 RPTPs are selective regulators of receptor tyrosine kinase (RTK) signaling, and a number of different RTKs have been shown to be direct targets for their phosphatase activities. Genetic studies in both invertebrate model systems and in mammals have shown that R3 RPTPs are essential for tubular organ development. They also have important functions during nervous system development. R3 RPTPs are likely to be tumor suppressors in a number of types of cancer.

Additional Information

© 2014 Elsevier B. V. Available online 19 September 2014. This work was supported by an NIH R21 grant to K.Z., HD0773367. We thank Peter Lee for discussions and communication of unpublished data, and Matthew Scott for hosting M.J. in his laboratory and for helpful discussions.

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