CaltechAUTHORS
Published September 2021 | Version Published
Journal Article Open

Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions

Creators

  • 1. ROR icon Dartmouth College
  • 2. ROR icon Ghent University
  • 3. ROR icon University of Zurich
  • 4. ROR icon University of Michigan–Ann Arbor
  • 5. ROR icon University of Pittsburgh
  • 6. ROR icon Imperial College London
  • 7. ROR icon University of Iowa
  • 8. ROR icon University of Colorado Anschutz Medical Campus
  • 9. ROR icon Columbia University
  • 10. ROR icon University of Minnesota
  • 11. ROR icon University of Guelph
  • 12. ROR icon Emory University
  • 13. ROR icon University of Warwick
  • 14. ROR icon University of Massachusetts System
  • 15. ROR icon Brigham and Women's Hospital
  • 16. ROR icon California Institute of Technology
  • 17. ROR icon Manchester Metropolitan University
  • 18. ROR icon McGill University
  • 19. ROR icon University of Nottingham
  • 20. ROR icon University of Oregon
  • 21. ROR icon Yale University
  • 22. ROR icon University of Illinois Urbana-Champaign
  • 23. ROR icon University of California, Irvine

Abstract

A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.

Additional Information

© 2021 O'Toole et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. Published 21 September 2021. We thank the Cystic Fibrosis Foundation's willingness to support the original, in-person version of this workshop, which needed to be canceled and rescheduled as a virtual event due to the COVID-19 pandemic. We thank Madison Leonard and Cindy Stewart of DartCF for their administrative support, Fabrice Jean-Pierre for his assistance, and the workshop session moderators (A. Crabbé, J. Bomberger, V. Phelan, J. Davies, D. Limoli, R. Kümmerli) and scribes (T. Hampton, R. Hunter, L. Dietrich, A. Price-Whelan, C. Khursigara, J. Bliska, W. DePas) for their willingness to help both the planning of and logistical support during the workshop. DartCF is supported by the NIH (P30-DK117469) and the Cystic Fibrosis Foundation Research Development Program (STANTO19R0). Additional support was provided by NIH/R01AI155424, NIH/1R01HL152190, CFF/CRAMER19GO, CIHR/PJT-156111, NIH/R35GM128690, NIH/R01DK104847, R01/NIHAI127548, CFF/TURNER19PO, NIH/R01HL136919, CFF/ASHARE21G0, NIH/R35HL18500, NIH/P20GM130454, NIHR Systematic Reviews Program, CFF/WHITEL20A0, NIH/R01AI103369, University of Nottingham Anne McLaren Fellowship, Swiss National Science Foundation/31003A_182499, MRC/MR/R001898/1, NIH/R01HL151385, NIH/R01AI155424, CFF/BOMBER21R3, CFF/SPERO19F0, NIH/R01HL136647, Paul G. Allen Frontiers Investigator Award, NIH/R01HL136647, Cystic Fibrosis Trust Strategic Research Centre Award, CF Trust/VIA078, CF Trust/VIAO77, CIHR/FDN/159902, and CFF/BOMBER18G0.

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Additional details

Identifiers

PMCID
PMC8546538
Eprint ID
111911
Resolver ID
CaltechAUTHORS:20211116-212551206

Funding

NIH
P30-DK117469
Cystic Fibrosis Foundation
STANTO19R0
NIH
R01AI155424
NIH
1R01HL152190
Cystic Fibrosis Foundation
CRAMER19GO
Canadian Institutes of Health Research (CIHR)
PJT-156111
NIH
R35GM128690
NIH
R01DK104847
NIH
NIHAI127548
Cystic Fibrosis Foundation
TURNER19PO
NIH
R01HL136919
Cystic Fibrosis Foundation
ASHARE21G0
NIH
R35HL18500
NIH
P20GM130454
National Institute for Health Research
Cystic Fibrosis Foundation
WHITEL20A0
NIH
R01AI103369
University of Nottingham
Swiss National Science Foundation (SNSF)
31003A_182499
Medical Research Council (UK)
MR/R001898/1
NIH
R01HL151385
NIH
R01AI155424
Cystic Fibrosis Foundation
BOMBER21R3
Cystic Fibrosis Foundation
SPERO19F0
NIH
R01HL136647
Paul G. Allen Family Foundation
Cystic Fibrosis Foundation
VIA078
Cystic Fibrosis Foundation
VIAO77
Canadian Institutes of Health Research (CIHR)
FDN/159902
Cystic Fibrosis Foundation
BOMBER18G0

Dates

Created
2021-11-16
Created from EPrint's datestamp field
Updated
2021-11-16
Created from EPrint's last_modified field

Caltech Custom Metadata

Caltech groups
Division of Geological and Planetary Sciences (GPS), Division of Biology and Biological Engineering (BBE)