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Published September 29, 2006 | Supplemental Material
Journal Article Open

Rhenium-Catalyzed 1,3-Isomerization of Allylic Alcohols: Scope and Chirality Transfer


The scope of the triphenylsilyl perrhennate (O_3ReOSiPh_3, 1) catalyzed 1,3-isomerization of allylic alcohols has been thoroughly explored. It was found to be effective for a wide variety of secondary and tertiary allylic alcohol substrates bearing aryl, alkyl, and cyano substituents. Two general reaction types were found which gave high levels of product selectivity:  those driven by formation of an extended conjugated system and those driven by selective silylation of a particular isomer. The efficiency of chirality transfer with various substrates was investigated, and conditions were found in which secondary and tertiary allylic alcohols could be formed with high levels of enantioselectivity. Consideration of selectivity trends with respect to the nature of the substituents around the allylic system revealed that this is a reliable and predictable method for allylic alcohol synthesis.

Additional Information

© 2006 American Chemical Society. Received 10 July 2006. Published online 7 September 2006. Published in print 1 September 2006. The authors thank the National Institutes of Health for financial support, Prof. Donald R. Deardorff and Jeffery Cannon at Occidental College for assistance with oxynitrilase reactions, and Prof. Dan O'Leary of Pomona College for assistance with NOESY spectra.

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Supplemental Material - jo061436lsi20060710_073430.pdf

Supplemental Material - jo061436lsi20060803_063223.pdf


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