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Published May 15, 2000 | Published
Journal Article Open

Frequency-swept ultrasound-modulated optical tomography in biological tissue by use of parallel detection


A frequency-swept ultrasonic beam was focused into a biological tissue sample to modulate the laser light passing through the ultrasonic beam inside the tissue. Parallel detection of the speckle field formed by the transmitted laser light was implemented with the source-synchronous-illumination lock-in technique to improve the signal-to-noise ratio. The ultrasound-modulated laser light reflects the local optical and mechanical properties in the ultrasonic beam and can be used for tomographic imaging of the tissue. Sweeping the ultrasonic frequency provides spatial resolution along the ultrasonic axis, which is scalable with the frequency span of the sweep. Two-dimensional images of biological tissue with buried objects were successfully obtained experimentally.

Additional Information

© 2000 Optical Society of America. Received January 7, 2000. This project was sponsored in part by National Institutes of Health grants R29 CA68562, R01 CA71980, and R21 CA83760 and by National Science Foundation grant BES-9734491.

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