Flow optimization study of a batch microfluidics PET tracer synthesizing device
Abstract
We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
Additional Information
© 2010 The Author(s). This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Published online: 12 November 2010. This work was funded by Siemens Molecular Imaging, Biomarker Research, Culver City, CA and by the Institute for Collaborative Biotechnologies throughcontract no. W911NF-09-D-0001 from the U.S. Army Research Office. The content of the information herein does not necessarily reflect the position or policy of the Government and no official endorsement should be inferred.Attached Files
Published - Elizarov2011p12754Biomed_Microdevices.pdf
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Additional details
- PMCID
- PMC3028087
- Eprint ID
- 22584
- Resolver ID
- CaltechAUTHORS:20110301-113228946
- Siemens Molecular Imaging
- Army Research Office (ARO)
- W911NF-09-D-0001
- Created
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2011-03-03Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field
- Caltech groups
- Kavli Nanoscience Institute