Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes
The asymmetric hydrogenation of heteroarenes has recently emerged as an effective strategy for the direct access to enantioenriched, saturated heterocycles. Although several homogeneous catalyst systems have been extensively developed for the hydrogenation of heteroarenes with high levels of chemo- and stereoselectivity, the development of mild conditions that allow for efficient and stereoselective hydrogenation of a broad range of substrates remains a challenge. This Perspective highlights recent advances in homogeneous catalysis of heteroarene hydrogenation as inspiration for the further development of asymmetric hydrogenation catalysts, and addresses underdeveloped areas and limitations of the current technology.
Additional Information© 2020 American Chemical Society. Received: September 9, 2020; Revised: October 15, 2020; Published: November 12, 2020. We thank NIH-NIGMS (R01GM127972A) and Caltech for funding and the support of our research program. The authors declare no competing financial interest.
Accepted Version - nihms-1662604.pdf