Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy
We previously demonstrated that multimodal microscopy combining photoacoustic microscopy and optical coherence tomography can provide comprehensive insight into biological tissue at μm-level resolution by exploiting both optical absorption and scattering contrasts. Recently, we have developed a second-generation integrated photoacoustic and optical-coherence microscope, which can potentially be adapted for clinical applications. In this new system, we can perform photoacoustic and optical-coherence imaging simultaneously at a speed of 5,000 A-lines per second with real-time on-screen display. Also, both modalities now work in reflection mode instead of transmission mode, allowing easy access to various anatomical locations of interest. Imaging of skin and eye has been demonstrated in living small animals.
Additional Information© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported by National Institutes of Health Grants R01 EB000712, R01 EB008085, R01 CA092415, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
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