Dendritic Tiling: New Insights from Genetics

Abstract

Two papers in the current issues of Neuron (Gallegos and Bargmann) and Cell (Emoto et al.) identify a conserved kinase, SAX-1/Trc, and a large protein required for Trc activity, SAX-2/Fry, as essential elements in the control of dendritic branching and tiling in Drosophila and C. elegans. The tiling and ectopic branching phenotypes of trc mutants appear to be independently generated. Thus, this kinase is the first signaling protein to be associated specifically with tiling.

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