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Published February 23, 2010 | Published
Book Section - Chapter Open

Invasive and transcranial photoacoustic imaging of the vascular response to brain electrical stimulation


Advances in the brain functional imaging greatly facilitated the understanding of neurovascular coupling. For monitoring of the microvascular response to the brain electrical stimulation in vivo we used optical-resolution photoacoustic microscopy (OR-PAM) through the cranial openings as well as transcranially. Both types of the vascular response, vasoconstriction and vasodilatation, were clearly observed with good spatial and temporal resolution. Obtained results confirm one of the primary points of the neurovascular coupling theory that blood vessels could present vasoconstriction or vasodilatation in response to electrical stimulation, depending on the balance between inhibition and excitation of the different parts of the elements of the neurovascular coupling system.

Additional Information

© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors thank Dr. Alexey Glukhov for technical support, and Prof. Sandra Matteucci for help in editing the manuscript. This work was supported by National Institutes of Health Grants R01 EB000712, R01 NS46214, R01 EB008085, R01 CA113453901, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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