Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published March 1941 | Published
Journal Article Open

The formation of glycocyamine in animal tissues


It was shown in preceding communications that glycocyamine is converted into creatine by surviving liver slices (1). Our findings indicated that the methylating agent is methionine or a derivative of methionine. Liver slices can methylate glycocyamine rapidly enough to permit assignment to the liver alone, if necessary, of the task of making good the loss of creatine and creatinine in the urine. This holds for the livers of all mammals studied. We found no evidence of this methylating mechanism in any other tissues, except possibly slight activity in the kidney. In the pigeon the kidney is as effective in this respect as the liver.

Additional Information

© 1941 American Society of Biological Chemists. Received for publication, September 18, 1940. A summary of this work has appeared (Science, 91, 551 (1940)).

Attached Files

Published - BORjbc41b.pdf


Files (813.4 kB)
Name Size Download all
813.4 kB Preview Download

Additional details

August 21, 2023
October 17, 2023