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Published January 2010 | Published
Journal Article Open

Real-time photoacoustic tomography of cortical hemodynamics in small animals


For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.

Additional Information

© 2010 SPIE. Paper 09486LR received Nov. 4, 2009; revised manuscript received Dec. 17, 2009; accepted for publication Dec. 28, 2009; published online Feb. 16, 2010. We thank Yu Wang and Junjie Yao for helpful discussions. This work has been supported in part by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc. which, however, did not support this work.

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