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Published March 4, 2013 | Published
Book Section - Chapter Open

Photoacoustic endoscopic imaging study of melanoma tumor growth in a rat colorectum in vivo


We performed a photoacoustic endoscopic imaging study of melanoma tumor growth in a nude rat in vivo. After inducing the tumor at the colorectal wall of the animal, we monitored the tumor development in situ by using a photoacoustic endoscopic system. This paper introduces our experimental method for tumor inoculation and presents imaging results showing the morphological changes of the blood vasculature near the tumor region according to the tumor progress. Our study could provide insights for future studies on tumor development in small animals.

Additional Information

© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Seema Dahlheimer for her attentive reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 CA157277, R01 NS46214 (BRP), R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.

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