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Published November 9, 2016 | Published + Supplemental Material
Journal Article Open

Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity


Computations in brain circuits involve the coordinated activation of large populations of neurons distributed across brain areas. However, monitoring neuronal activity in the brain of intact animals with high temporal and spatial resolution has remained a technological challenge. Here we address this challenge by developing dense, three-dimensional (3-D) electrode arrays for electrophysiology. The 3-D arrays constitute the front-end of a modular and configurable system architecture that enables monitoring neuronal activity with unprecedented scale and resolution.

Additional Information

© 2016 American Chemical Society. ACS Editors' Choice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received: June 28, 2016. Revised: September 17, 2016. Publication Date (Web): October 21, 2016. Foundry fabrication was carried out at CEA/LETI, Grenoble under the aegis of the Alliance for Nanosystems VLSI; we especially thank Denis Renaud, Eric Rouchouze, and Hughes Metras for their help. We thank Jennifer Mok for histological processing of brains from the in vivo experiments. This work was supported by the Mathers Foundation, the Beckman Institute at Caltech, the Moore Foundation, and the NIH (1DP1OD008255/5DP1MH099907). Author Contributions: G.R. and E.V.L. contributed equally to this work. System architecture and specification: G.R., E.V.L., M.L.R., A.G.S.; component design: G.R., E.V.L.; component mask layout: G.R., E.V.L.; component fabrication prototyping: G.R., D.C.; component foundry fabrication: G.R., E.V.L., M.L.R., A.G.S.; system packaging: G.R., E.V.L.; system software development: E.V.L.; system benchtop evaluation: G.R., E.V.L.; system in vivo evaluation: G.R., E.V.L., A.G.S.; manuscript preparation and figure creation: G.R., E.V.L. with input from A.G.S., M.L.R., D.C. The authors declare no competing financial interest.

Attached Files

Published - acs.nanolett.6b02673.pdf

Supplemental Material - nl6b02673_si_001.pdf


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